Deion Sanders and his Colorado Buffaloes tried to rally in the second half against the eighth-ranked USC Trojans but came up short, losing 48-41 on Saturday in Boulder, Colorado.
Also losing were bettors who backed Heisman Trophy winner Caleb Williams and the Trojans, who were favored by 21.5 points.
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The Trojans raced out to a 21-0 lead by the first play of the second quarter.
USC led 34-7 with less than three minutes to go in the first half, but the Buffaloes scored with 21 seconds left to make it 34-14 at the break.
No. 8 USC Trojans vs. Colorado Buffaloes highlights
The Trojans led 41-14 midway through the third quarter before quarterback Shedeur Sanders rallied the Buffaloes.
Colorado outscored USC 27-7 the rest of the way as Trojans bettors ripped up their tickets.
The teams combined for 41 points in the second half to zoom past the Over/Under total of 72.5.
Also suffering a tough betting loss were bettors who played USC Over 48.5 team total points.
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