2023 NFL Week 10 odds, predictions: Picks, lines, spreads for every game

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The San Francisco 49ers (5-3) play at the Jacksonville Jaguars (6-2) in one of the marquee matchups of NFL Week 10 on Sunday.

The 49ers, coming off a bye, are the co-leaders of the NFC West Division with the Seattle Seahawks.

The Jaguars lead the AFC South.

The game will be at 1 p.m. ET Sunday and can be seen on FOX and the FOX Sports App.

The New York Giants and Dallas Cowboys resume one of the league’s most storied rivalries in Texas. The game is at 4:25 p.m. ET on Sunday and can be seen on FOX and the FOX Sports App.

Here’s everything you need to know about the NFL odds for Week 10 — the point spread, moneyline and total Over/Under.

All times ET

BYES: Chiefs, Dolphins, Eagles, Rams

THURSDAY’S GAME

Panthers @ Bears (8:15 p.m., Amazon Prime Video)

Point spread: Bears -2 (Bears favored to win by more than 2 points, otherwise Panthers cover)
Moneyline: Bears -130 favorites to win (bet $10 to win $17.69 total); Panthers +110 underdogs to win (bet $10 to win $21 total)
Total scoring Over/Under: 41.5 points scored by both teams combined

Carolina Panthers

CAR

Chicago Bears

CHI

Josh Dobbs reflects on being traded to the Vikings, leading them to a win

SUNDAY’S GAMES

Colts vs. Patriots @ Frankfurt, Germany (9:30 a.m., NFL Network)

Point spread: Patriots -1 (Patriots favored to win by more than 1 point, otherwise Colts cover)
Moneyline: Patriots -120 favorites to win (bet $10 to win $18.33 total); Colts +100 underdogs to win (bet $10 to win $20 total)
Total scoring Over/Under: 44 points scored by both teams combined

Indianapolis Colts

IND

New England Patriots

Saints @ Vikings (1 p.m., FOX and FOX Sports App)

Point spread: Saints -3 (Saints favored to win by more than 3 points, otherwise Vikings cover)
Moneyline: Saints -148 favorites to win (bet $10 to win $16.76 total); Vikings +125 underdogs to win (bet $10 to win $22.50 total)
Total scoring Over/Under: 41 points scored by both teams combined

New Orleans Saints

Minnesota Vikings

MIN

49ers @ Jaguars (1 p.m., FOX and FOX Sports App)

Point spread: 49ers -2.5 (49ers favored to win by more than 2.5 points, otherwise Jaguars cover)
Moneyline: 49ers -135 favorites to win (bet $10 to win $17.41 total); Jaguars +115 underdogs to win (bet $10 to win $21.50 total)
Total scoring Over/Under: 44.5 points scored by both teams combined

San Francisco 49ers

Jacksonville Jaguars

JAX

Browns @ Ravens (1 p.m., FOX and FOX Sports App)

Point spread: Ravens -5 (Ravens favored to win by more than 5 points, otherwise Browns cover)
Moneyline: Ravens -228 favorites to win (bet $10 to win $14.39 total); Browns +185 underdogs to win (bet $10 to win $28.50 total)
Total scoring Over/Under: 40.5 points scored by both teams combined

Cleveland Browns

CLE

Baltimore Ravens

BAL

Texans @ Bengals (1 p.m., CBS)

Point spread: Bengals -10 (Bengals favored to win by more than 10 points, otherwise Titans cover)
Moneyline: Bengals -345 favorites to win (bet $10 to win $12.90 total); Titans +280 underdogs to win (bet $10 to win $38 total)
Total scoring Over/Under: 44.5 points scored by both teams combined

Houston Texans

HOU

Cincinnati Bengals

CIN

Packers @ Steelers (1 p.m., CBS)

Point spread: Steelers -3 (Steelers favored to win by more than 3 points, otherwise Packers cover)
Moneyline: Steelers -162 favorites to win (bet $10 to win $16.17 total); Packers +136 underdogs to win (bet $10 to win $23.60 total)
Total scoring Over/Under: 38 points scored by both teams combined

Green Bay Packers

Pittsburgh Steelers

PIT

Titans @ Buccaneers (1 p.m., CBS)

Point spread: Buccaneers -1.5 (Buccaneers favored to win by more than 1.5 points, otherwise Titans cover)
Moneyline: Buccaneers -120 favorites to win (bet $10 to win $18.33 total); Titans +100 underdogs to win (bet $10 to win $20 total)
Total scoring Over/Under: 39.5 points scored by both teams combined

Tennessee Titans

TEN

Tampa Bay Buccaneers

Falcons @ Cardinals (4:05 p.m., CBS)

Point spread: Falcons -2.5 (Falcons favored to win by more than 2.5 points, otherwise Cardinals cover)
Moneyline: Falcons -120 favorites to win (bet $10 to win $18.33 total); Cardinals +100 underdogs to win (bet $10 to win $20 total)
Total scoring Over/Under: 42 points scored by both teams combined

Atlanta Falcons

ATL

Arizona Cardinals

ARI

Lions @ Chargers (4:05 p.m., CBS)

Point spread: Lions -1 (Lions favored to win by more than 1 point, otherwise Chargers cover)
Moneyline: Lions -117 favorites to win (bet $10 to win $18.55 total); Chargers -102 underdogs to win (bet $10 to win $19.80 total)
Total scoring Over/Under: 48.5 points scored by both teams combined

Detroit Lions

DET

Los Angeles Chargers

LAC

Giants @ Cowboys (4:25 p.m., FOX and FOX Sports App)

Point spread: Cowboys -10 (Cowboys favored to win by more than 10 points, otherwise Giants cover)
Moneyline: Cowboys -500 favorites to win (bet $10 to win $1 total); Giants +375 underdogs to win (bet $10 to win $47.50 total)
Total scoring Over/Under: 41.5 points scored by both teams combined

New York Giants

NYG

Dallas Cowboys

DAL

Commanders @ Seahawks (4:25 p.m., FOX and FOX Sports App)

Point spread: Seahawks -6 (Seahawks favored to win by more than 6 points, otherwise Commanders cover)
Moneyline: Seahawks -271 favorites to win (bet $10 to win $13.69 total); Commanders +220 underdogs to win (bet $10 to win $32 total)
Total scoring Over/Under: 44.5 points scored by both teams combined

Washington Commanders

WAS

Seattle Seahawks

SEA

Jets @ Raiders (8:20 p.m., NBC)

Point spread: Jets -2.5 (Jets favored to win by more than 2.5 points, otherwise Raiders cover)
Moneyline: Jets -141 favorites to win (bet $10 to win $17.09 total); Raiders +120 underdogs to win (bet $10 to win $22 total)
Total scoring Over/Under: 36 points scored by both teams combined

New York Jets

NYJ

Las Vegas Raiders

MONDAY’S GAME

Broncos @ Bills (8:15 p.m. ET, ESPN/ABC)

Point spread: Bills -8 (Bills favored to win by more than 8 points, otherwise Broncos cover)
Moneyline: Bills -426 favorites to win (bet $10 to win $12.35 total); Broncos +325 underdogs to win (bet $10 to win $42.50 total)
Total scoring Over/Under: 46 points scored by both teams combined